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How Focuson Works

It's Science... Not Magic

The Focuson nutraceutical product acts as an all natural superfood to supercharge the brain. It's a scientific health supplement specifically developed to assist concentration, motivation, memory and mood.

Natural Ingredients Supporting Natural Processes

Synaptic plasticity is the ability of chemical synapses in the brain to change their strength and it is our specific formulation of very carefully selected ingredients (some of which are exclusive to Level Up) that helps fuel synaptic plasticity. It is by supporting a process known as Long-Term Potentiation (LTP) that the formulation helps the brain produce an exaggerated response in the post-synaptic neuron which in turn leads to a stronger connection between the cells.

Focuson Increases LTP Focuson Cellular Diagram

It opens up certain neurological pathways.

It raises levels of cyclic adenosine monophosphate (cAMP)[4][5]. The activation of the transmembrane enzyme adenylate cyclase catalyzes the synthesis of cAMP from ATP (a molecular unit of currency). cAMP is a secondary messenger, that is, it intracellularly transmits the signal originated by the extracellular ligand. The cAMP pathway plays a central role in synaptic plasticity as amplifications of signals through this pathway lowers the threshold of generating long-lasting LTP.[6]

Focuson Formula Process

It inhibits the enzyme that breaks down those pathways.

The formulation inhibits Phosphodiesterase-4 (PDE4).[7] PDE4 is an enzyme that specifically hydrolyses cAMP, regulating cellular concentrations and thereby playing a role in signal transduction. By inhibiting PDE4 the degradative action on cAMP is blocked which results in increased cellular cAMP, and therefore increased signaling through cAMP-dependent pathways. In addition the inhibition of PDE4 is known to result in pro-cognitive[8] (including long-term memory-improving)[9], wakefulness-promoting[10], neuroprotective[11][12], and anti-inflammatory effects.[13]

Focuson Inhibits PDE4 and Raises cAMP

Balances Neurotransmitters and provides the needed building blocks

The formulation helps balance neurotransmitters. The difference in response (i.e. magnitude of persistence of the signal) within neurons depends on the activity of cAMPdependent protein kinase A (PKA, dependent on cellular levels of cAMP). In neurons, PKA helps transfer the dopamine signal into cells (i.e. increased dopamine efflux). To help support the increased dopamine metabolism and to balance out the upregulation of acetylcholinesterase expression, our formulation supplies all the precursor molecules needed while also aiding the creation of physiologically active amines by decarboxylation of amino acids (i.e. needed to produce neurotransmitters serotonin and dopamine).[14] [15][16]

Focuson Formula Helps Balance Neurotranmsitters

References


  1. Plasticity in the human central nervous system.
  2. A synaptic model of memory: long-term potentiation in the hippocampus.
  3. Selective phosphodiesterase inhibitors: a promising target for cognition enhancement.
  4. Forskolin, an inducer of cAMP, up-regulates acetylcholinesterase expression and protects against organophosphate exposure in neuro 2A cells.
  5. Proof-of-Concept Randomized Controlled Study of Cognition Effects of the Proprietary Extract Sceletium tortuosum (Zembrin) Targeting Phosphodiesterase-4 in Cognitively Healthy Subjects: Implications for Alzheimer's Dementia
  6. Inhibition of the cAMP pathway decreases early long-term potentiation at CA1 hippocampal synapses.
  7. Pharmacological actions of the South African medicinal and functional food plant Sceletium tortuosum and its principal alkaloids.
  8. Rolipram, a type IV-specific phosphodiesterase inhibitor, facilitates the establishment of long-lasting long-term potentiation and improves memory.
  9. Rolipram, an antidepressant that increases the availability of cAMP, transiently enhances wakefulness in rats.
  10. Rolipram reduces excitotoxic neuronal damage.
  11. Broad spectrum neuroprotection profile of phosphodiesterase inhibitors as related to modulation of cell-cycle elements and caspase-3 activation.
  12. Neuroprotective role of PDE4 and PDE5 inhibitors in 3-nitropropionic acid induced behavioral and biochemical toxicities in rats.
  13. Selective Phosphodiesterase Inhibitors for Psoriasis: Focus on Apremilast.
  14. Sustained phosphorylation of tyrosine hydroxylase at serine 40: a novel mechanism for maintenance of catecholamine synthesis.
  15. Effect of vitamin B-6 nutrition on the levels of dopamine, dopamine metabolites, dopa decarboxylase activity, tyrosine, and GABA in the developing rat corpus striatum.
  16. Acetyl-L-carnitine: from a biological curiosity to a drug for the peripheral nervous system and beyond.